Journal
METABOLITES
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/metabo10070279
Keywords
Tregs; Foxp3; T cells; metabolism; immunometabolism; atherosclerosis; hypercholesterolemia
Categories
Funding
- Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation
- Dutch Federation of University Medical Centres
- Netherlands Organization for Health Research and Development
- Royal Netherlands Academy of Sciences [CVON2017-20]
- Deutsche Forschungsgemeinschaft [CRC 1123]
- European Research Council (ERC) [681493]
- European Research Council (ERC) [681493] Funding Source: European Research Council (ERC)
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Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a chronic inflammatory disease of the arterial wall and the leading cause of cardiovascular disease. Therefore, therapeutic strategies to improve Treg number or function could be beneficial to preventing atherosclerotic disease development. A growing body of evidence shows that intracellular metabolism of Tregs is a key regulator of their proliferation, suppressive function, and stability. Here we evaluate the role of Tregs in atherosclerosis, their metabolic regulation, and the links between their metabolism and atherosclerosis.
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