Journal
METABOLITES
Volume 10, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/metabo10060258
Keywords
microbial metabolites; urolithins; monoamine oxidase
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Funding
- NIH/NCI [CA191683, R21CA216090]
- NIH/NIGMS CoBRE grant [P20GM125504-01]
- Jewish Heritage Fund for Excellence Research Enhancement Grant
- JGBCC
- Department of Biotechnology (DBT) [BT/PR12490/AAQ/3/716/2015]
- Institute for Stem Cell Science and Regenerative Medicine (inStem)
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Urolithins are gut microbial metabolites derived from ellagitannins (ET) and ellagic acid (EA), and shown to exhibit anticancer, anti-inflammatory, anti-microbial, anti-glycative and anti-oxidant activities. Similarly, the parent molecules, ET and EA are reported for their neuroprotection and antidepressant activities. Due to the poor bioavailability of ET and EA, the in vivo functional activities cannot be attributed exclusively to these compounds. Elevated monoamine oxidase (MAO) activities are responsible for the inactivation of monoamine neurotransmitters in neurological disorders, such as depression and Parkinson's disease. In this study, we examined the inhibitory effects of urolithins (A, B and C) and EA on MAO activity using recombinant human MAO-A and MAO-B enzymes. Urolithin B was found to be a better MAO-A enzyme inhibitor among the tested urolithins and EA with an IC(50)value of 0.88 mu M, and displaying a mixed mode of inhibition. However, all tested compounds exhibited higher IC50(>100 mu M) for MAO-B enzyme.
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