Journal
FRONTIERS IN SYSTEMS NEUROSCIENCE
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnsys.2020.00022
Keywords
Up and Down states; memory consolidation; sleep; somatosensory cortex; entorhinal cortex; hippocampus; inhibition; neuromodulation
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [LA 3442/6-1, LA 3442/3-1, LA 3442/5-1]
- DFG [327654276 -SFB 1315]
- European Commission Horizon 2020 Research and Innovation Program [670118]
- European Commission Euratom Research and Training Program 2014-2018 [670118]
- Human Brain Project HBP FPA [650003, 720270]
- Einstein Foundation Berlin [EVF-2017-363, A-2016-311]
- Stiftung Charite
- ERC BrainPlay-Synergy grant
- DFG NeuroCure Cluster of Excellence [EXC-2049-390688087]
- European Research Council (ERC) [670118] Funding Source: European Research Council (ERC)
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In the course of a day, brain states fluctuate, from conscious awake information-acquiring states to sleep states, during which previously acquired information is further processed and stored as memories. One hypothesis is that memories are consolidated and stored during offline states such as sleep, a process thought to involve transfer of information from the hippocampus to other cortical areas. Up and Down states (UDS), patterns of activity that occur under anesthesia and sleep states, are likely to play a role in this process, although the nature of this role remains unclear. Here we review what is currently known about these mechanisms in three anatomically distinct but interconnected cortical areas: somatosensory cortex, entorhinal cortex, and the hippocampus. In doing so, we consider the role of this activity in the coordination of replay during sleep states, particularly during hippocampal sharp-wave ripples. We conclude that understanding the generation and propagation of UDS may provide key insights into the cortico-hippocampal dialogue linking archi- and neocortical areas during memory formation.
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