Journal
MICROORGANISMS
Volume 8, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms8060860
Keywords
FML; lipid metabolism; gut microbiota; acetic acid; microbiota transplantation
Categories
Funding
- National Natural Science Foundation of China [31802077, U19A2037, 31972582]
- Innovation Team in Key Area Innovation Team of Physiology and Metabolism and Body Health in Pig [2019RS3022]
- National Key R D Program [2018YFD0500405]
- Science and Technology Project of Guangxi Province [2018JJB130239]
- Earmarked Fund for China Agriculture Research System [CARS-35]
- Special funds for the construction of innovative provinces in Hunan Project [2019NK2193]
- 'Strategic Priority Research Program' of the Chinese Academy of Sciences [XDA24030204]
- Open Fund of Key Laboratory of Agro-ecological Processes in Subtropical Region, Chinese Academy of Sciences [ISA2020203, ISA2019201, ISA2019304]
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Here, we investigated the roles and mechanisms of flavonoids from mulberry leaves (FML) on lipid metabolism in high fat diet (HFD)-fed mice. ICR mice were fed either a control diet (Con) or HFD with or without FML (240 mg/kg/day) by oral gavage for six weeks. FML administration improved lipid accumulation, alleviated liver steatosis and the whitening of brown adipose tissue, and improved gut microbiota composition in HFD-fed mice. Microbiota transplantation from FML-treated mice alleviated HFD-induced lipid metabolic disorders. Moreover, FML administration restored the production of acetic acid in HFD-fed mice. Correlation analysis identified a significant correlation between the relative abundances ofBacteroidetesand the production of acetic acid, and between the production of acetic acid and the weight of selected adipose tissues. Overall, our results demonstrated that in HFD-fed mice, the lipid metabolism improvement induced by FML administration might be mediated by gut microbiota, especiallyBacteroidetes-triggered acetic acid production.
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