Journal
BIOMOLECULES
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/biom10071068
Keywords
mitochondria; mitochondrial pyruvate carrier; metabolism; neurodegeneration; metabolic disorders; cancer
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Funding
- Swiss National Science Foundation [31003A_179421]
- Oncosuisse [KFS-4434-02-2018]
- Swiss National Science Foundation (SNF) [31003A_179421] Funding Source: Swiss National Science Foundation (SNF)
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Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerative diseases, metabolic disorders, and cancer.
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