Journal
APPLIED MATERIALS TODAY
Volume 19, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apmt.2020.100601
Keywords
Carbon quantum dots; Antibacterial; Non-hemolytic; Biocompatible; Wound healing
Categories
Funding
- National Natural Science Foundationof China [81460107, 31530024, 31872748, 81925027]
- NationalKey R&D Program of China [2016YFC1100203]
- Jiangsu ProvincialSpecial Program of Medical Science [BL2012004]
- PriorityAcademic Program Development (PAPD) of Jiangsu Higher Education Institutions
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Effectively targeting and killing microbial pathogens is a major challenge in the treatment of infectious diseases. Inspired by the high efficacy of natural antimicrobial peptides (AMPs), in this study we prepared two types of carbon quantum dots (CQDs) by pyrolysis of lysine and arginine, the two major functional moieties of natural AMPs. Both lysine-derived CQDs (Lys-CQDs) and arginine-derived CQDs (Arg-CQDs) exhibited distinctive antibacterial activity against both Gram-negative and Gram-positive bacteria without inducing drug resistance. They also effectively inhibited the formation of bacterial biofilms. Such excellent antibacterial properties might be the result of positive charges derived from the amino acid residues on CQD surface and the generation of rich intracellular reactive oxygen species (ROS). Surprisingly, instead of being cytotoxic, CQDs dramatically promoted the growth of typical mammalian cells. Moreover, no hemolysis of red blood cells (RBCs) happened when CQD concentration was less than 4,000 mu g/mL. In vivo , administration of CQDs to infected wounds effectively inhibited bacterium growth and accelerated wound healing. Together, findings from this study indicate that Lys-CQDs and Arg-CQDs can simultaneously kill bacteria and facilitate cell growth, and may therefore be promising candidates for treating bacterial infections and promoting tissue repair. (C) 2020 Elsevier Ltd. All rights reserved.
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