Journal
GEROSCIENCE
Volume 43, Issue 2, Pages 487-505Publisher
SPRINGER
DOI: 10.1007/s11357-020-00209-w
Keywords
Oxidative stress; RNA damage; RNA control systems; Aging; Disorders
Categories
Funding
- National Natural Science Foundation of China [81703036, 81803035]
- China Postdoctoral Science Foundation [2017M610510]
- Natural Science Foundation of Hunan Province, China [2019JJ50932]
Ask authors/readers for more resources
RNA molecules are vulnerable to oxidative stress, with 8-oxoG being a promising biomarker for measuring oxidative stress and aging-related diseases. RNA oxidation has significant implications for signaling pathways and gene regulation in aging-related diseases, emphasizing the importance of considering multiple RNA oxidation adducts in research and clinical trials.
Ribonucleic acid (RNA) molecules can be easily attacked by reactive oxygen species (ROS), which are produced during normal cellular metabolism and under various oxidative stress conditions. Numerous findings report that the amount of cellular 8-oxoG, the most abundant RNA damage biomarker, is a promising target for the sensitive measurement of oxidative stress and aging-associated diseases, including neuropsychiatric disorders. Most importantly, available data suggest that RNA oxidation has important implications for various signaling pathways and gene expression regulation in aging-related diseases, highlighting the necessity of using combinations of RNA oxidation adducts in both experimental studies and clinical trials. In this review, we primarily describe evidence for the effect of oxidative stress on RNA integrity modulation and possible quality control systems. Additionally, we discuss the profiles and clinical implications of RNA oxidation products that have been under intensive investigation in several aging-associated medical disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available