Drug-drug cocrystals: Opportunities and challenges

Recently, drug-drug cocrystal attracts more and more attention. It offers a low risk, low-cost but high reward route to new and better medicines and could improve the physiochemical and biopharmaceutical properties of a medicine by addition of a suitable therapeutically effective component without any chemical modification. Having so many advantages, to date, the reported drug-drug cocrystals are rare. Here we review the drug-drug cocrystals that reported in last decade and shed light on the opportunities and challenges for the development of drug-drug cocrystals. (C) 2020 Shenyang Pharmaceutical University. Published by Elsevier B.V.

Automated summary

Drug-drug cocrystals have advantages of low risk, low cost, and high reward, improving the properties of medicines without chemical modifications. However, reported cases are rare, highlighting opportunities and challenges for their development.