Journal
CELLS
Volume 9, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cells9071632
Keywords
TCTP (HRF; fortilin); growth and development; biological stress reactions; autophagy; regulation of protein synthesis; regulated protein degradation; cancer; cardiovascular diseases
Categories
Funding
- Wellcome Trust (UK)
- Illawarra Health and Medical Research Institute
- Graduate School of Medicine, University of Wollongong, NSW, Australia
- French National Agency for Research ANR [ANR-09-BLAN-0292]
- European Union Network of Excellence CONTICANET, LabEx LERMIT, INCa Projets [libres de 2013-1-PLBIO-10-IGR-1]
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0292] Funding Source: Agence Nationale de la Recherche (ANR)
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Translationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF) or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is involved in a range of basic cell biological processes, such as promotion of growth and development, or cellular defense in response to biological stresses. Cellular TCTP levels are highly regulated in response to a variety of physiological signals, and regulatory mechanism at various levels have been elucidated. Given the importance of TCTP in maintaining cellular homeostasis, it is not surprising that dysregulation of this protein is associated with a range of disease processes. Here, we review recent progress that has been made in the characterisation of the basic biological functions of TCTP, in the description of mechanisms involved in regulating its cellular levels and in the understanding of dysregulation of TCTP, as it occurs in disease processes such as cancer.
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