Journal
CELLS
Volume 9, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cells9071624
Keywords
MASTL; actin; contractility; cell cycle; cancer; therapeutic targeting; kinase inhibitor
Categories
Funding
- Academy of Finland [325464]
- Sigrid Juselius Foundation
- Finnish Cancer Organization
- Finnish Cultural Foundation
- European Union [841973]
- Academy of Finland (AKA) [325464, 325464] Funding Source: Academy of Finland (AKA)
- Marie Curie Actions (MSCA) [841973] Funding Source: Marie Curie Actions (MSCA)
Ask authors/readers for more resources
Microtubule-associated serine/threonine kinase-like (MASTL; Greatwall) is a well-characterized kinase, whose catalytic role has been extensively studied in relation to cell-cycle acceleration. Importantly, MASTL has been implicated to play a substantial role in cancer progression and subsequent studies have shown that MASTL is a significant regulator of the cellular actomyosin cytoskeleton. Several kinases have non-catalytic properties, which are essential or even sufficient for their functions. Likewise, MASTL functions have been attributed both to kinase-dependent phosphorylation of downstream substrates, but also to kinase-independent regulation of the actomyosin contractile machinery. In this review, we aimed to highlight the catalytic and non-catalytic roles of MASTL in proliferation, migration, and invasion. Further, we discussed the implications of this dual role for therapeutic design.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available