4.5 Article

Polymeric Composite Dressings Containing Calcium-Releasing Nanoparticles Accelerate Wound Healing in Diabetic Mice

Journal

ADVANCES IN WOUND CARE
Volume 10, Issue 6, Pages 301-316

Publisher

MARY ANN LIEBERT, INC
DOI: 10.1089/wound.2020.1206

Keywords

chronic wounds; bioactive dressings; diabetes; angiogenesis

Categories

Funding

  1. Spanish Ministry of Economy and Competitiveness (MINECO/FEDER) [MAT2012-38793, MAT2015-68906-R]
  2. Spanish Ministry of Science and Innovation [PCI2019-103648]
  3. Spanish Ministry of Education, Culture, and Sports [AP-2012-5310]
  4. EIT Health [EIT PoC-2016-SPAIN-03]
  5. La Caixa Banking Foundation through CaixaImpulse Program
  6. La Caixa Banking Foundation through Caixaimpulse 2.0 Consolidate Program [LCF/TR/CN18/52210003]
  7. SerraHunter program

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The developed polymeric composite dressing containing ion-releasing nanoparticles has shown significant efficacy in accelerating chronic wound healing. This novel dressing not only promotes angiogenesis and collagen synthesis but also accelerates wound closure. Compared to commercially available dressings, the newly designed composite demonstrates superior performance in chronic wound treatment.
Objective: Wound healing is a complex process that involves the interaction between different cell types and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of these interactions, resulting in nonhealing chronic wounds. Chronic wounds are a socioeconomic burden, one of the most prominent clinical manifestations of diabetes, however, they lack satisfactory treatment options. The objective of this study was to develop polymeric composites that deliver ions having wound healing properties and evaluate its performance using a pressure ulcer model in diabetic mice. Approach: To develop a polymeric composite wound dressing containing ion-releasing nanoparticles for chronic wound healing. This composite was chemically and physically characterized and evaluated using a pressure ulcer wound model in diabetic (db/db) mice to explore their potential as novel wound dressing. Results: This dressing exhibits a controlled ion release and a goodin vitrobioactivity. The polymeric composite dressing treatment stimulates angiogenesis, collagen synthesis, granulation tissue formation, and accelerates wound closure of ischemic wounds created in diabetic mice. In addition, the performance of the newly designed composite is remarkably better than a commercially available dressing frequently used for the treatment of low-exuding chronic wounds. Innovation: The developed nanoplatforms are cell- and growth factor free and control the host microenvironment resulting in enhanced wound healing. These nanoplatforms are available by cost-effective synthesis with a defined composition, offering an additional advantage in potential clinical application. Conclusion: Based on the obtained results, these polymeric composites offer an optimum approach for chronic wound healing without adding cells or external biological factors.

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