Journal
CANCERS
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/cancers12082123
Keywords
DNA methyltransferases; cancer; DNMT aberrations; therapy
Categories
Funding
- National Natural Science Foundation of China [81773216, 81673652, 81973365]
- Natural Science Foundation of Liaoning Province [20170540841, 20180550076]
- Xingliao Talents Program of Liaoning Province [XLYC1902008]
- Youth Science and Technology Innovation Leader Program of Shenyang [RC190457]
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DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals, DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal biological functions, such as embryo development, cell differentiation and gene transcription. Aberrant functions of DNMTs are frequently associated with tumorigenesis. DNMT aberrations usually affect tumor-related factors, such as hypermethylated suppressor genes and genomic instability, which increase the malignancy of tumors, worsen the prognosis for patients, and greatly increase the difficulty of cancer therapy. However, the impact of DNMTs on tumors is still controversial, and therapeutic approaches targeting DNMTs are still under exploration. Here, we summarize the biological functions and paradoxes associated with DNMTs and we discuss some emerging strategies for targeting DNMTs in tumors, which may provide novel ideas for cancer therapy.
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