Journal
CANCERS
Volume 12, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/cancers12061452
Keywords
mechanosensation; mechanotransduction; mechanoresponsiveness; mechanobiology; breast cancer; stiffness; interstitial fluid pressure; solid stress
Categories
Funding
- METAvivor foundation
- Veterans Administration [I01-BX002746]
- Air ForceOffice of Scientific Research [FA9550-16-1-0052]
- National Institutes of Health [R01-CA124704, R01-CA154624, 5T32GM008181-30, 1F31CA232393-01]
- Maryland Cigarette Restitution Fund
- [P30-CA134274]
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Mechanotransduction is the interpretation of physical cues by cells through mechanosensation mechanisms that elegantly translate mechanical stimuli into biochemical signaling pathways. While mechanical stress and their resulting cellular responses occur in normal physiologic contexts, there are a variety of cancer-associated physical cues present in the tumor microenvironment that are pathological in breast cancer. Mechanistic in vitro data and in vivo evidence currently support three mechanical stressors as mechanical modifiers in breast cancer that will be the focus of this review: stiffness, interstitial fluid pressure, and solid stress. Increases in stiffness, interstitial fluid pressure, and solid stress are thought to promote malignant phenotypes in normal breast epithelial cells, as well as exacerbate malignant phenotypes in breast cancer cells.
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