Journal
CANCERS
Volume 12, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cancers12071723
Keywords
carbonic anhydrase; brain tumor; glioma; astrocytoma; oligodendroglioma; medulloblastoma; prognosticator; carbonic anhydrase inhibitor
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Funding
- Finnish Pediatric Research Foundation
- Pediatric Cancer Research Foundation Vare (Lasten syopasaatio Vare)
- Sigrid Juselius Foundation
- Jane & Aatos Erkko Foundation
- Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital
- Finnish Ministry of Social Affairs and Health
- Academy of Finland
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Carbonic anhydrases (CAs) are zinc-containing metalloenzymes that participate in the regulation of pH homeostasis in addition to many other important physiological functions. Importantly, CAs have been associated with neoplastic processes and cancer. Brain tumors represent a heterogeneous group of diseases with a frequently dismal prognosis, and new treatment options are urgently needed. In this review article, we summarize the previously published literature about CAs in brain tumors, especially on CA II and hypoxia-inducible CA IX and CA XII. We review here their role in tumorigenesis and potential value in predicting prognosis of brain tumors, including astrocytomas, oligodendrogliomas, ependymomas, medulloblastomas, meningiomas, and craniopharyngiomas. We also introduce both already completed and ongoing studies focusing on CA inhibition as a potential anti-cancer strategy.
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