Journal
CANCERS
Volume 12, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cancers12071787
Keywords
cancer; mitochondria; mitochondrial transfer; tunneling nanotubes; tumor microenvironment
Categories
Funding
- Czech Science Foundation [GA CR 19-25354Y]
- Institutional Development Plan of University of Ostrava [IRP03_2018-2020]
- New Directions of Biomedical Research in the Ostrava Region [CZ.02.1.01/0.0/0.0/18_069/0010060, SGS03/LF/2019-2020, SGS03/PrF/2019-2020]
- ERDF-Project ENOCH [CZ.02.1.01/0.0/0.0/16_019/0000868]
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Cell-to-cell communication is a fundamental process in every multicellular organism. In addition to membrane-bound and released factors, the sharing of cytosolic components represents a new, poorly explored signaling route. An extraordinary example of this communication channel is the direct transport of mitochondria between cells. In this review, we discuss how intercellular mitochondrial transfer can be used by cancer cells to sustain their high metabolic requirements and promote drug resistance and describe relevant molecular players in the context of current and future cancer therapy.
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