Journal
JOURNAL OF CLINICAL MEDICINE
Volume 9, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/jcm9082434
Keywords
breast density; body-mass index; adiposity; menopause; menopausal stage; mammogram
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The interrelationship between menopausal stage, excessive adiposity and dense breasts remains unclear. We aimed to investigate the relationship between menopausal stage and dense-breast prevalence in midlife women while considering a possible effect modification of being overweight. The present cross-sectional study comprised 82,677 Korean women, aged 35-65 years, who attended a screening exam. Menopausal stages were categorized based on the Stages of Reproductive Aging Workshop (STRAW + 10) criteria. Mammographic breast density was categorized according to Breast Imaging Reporting and Data System (BI-RADS). Dense breasts were defined as BI-RADS Breast Density category D (extremely dense). The prevalence of dense breasts decreased as menopausal stage increased (p-trend < 0.001), and this pattern was pronounced in overweight women than non-overweight women (p-interaction = 0.016). Compared with pre-menopause, the multivariable-adjusted prevalence ratios (and 95% confidence intervals) for dense breasts were 0.98 (0.96-1.00) in early transition, 0.89 (0.86-0.92) in late transition, and 0.55 (0.52-0.59) in post-menopause, among non-overweight women, while corresponding prevalence ratios were 0.92 (0.87-0.98), 0.83 (0.77-0.90) and 0.36 (0.31-0.41) among overweight women. The prevalence of dense breasts was inversely associated with increasing menopausal stages and significantly decreased from the late menopausal transition, with stronger declines among overweight women.
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