4.8 Article

Distortion matrix concept for deep optical imaging in scattering media

Journal

SCIENCE ADVANCES
Volume 6, Issue 30, Pages -

Publisher

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aay7170

Keywords

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Funding

  1. Labex WIFI (Laboratory of Excellence within the French Program Investments for the Future) [ANR-10-LABX-24, ANR-10-IDEX-0001-02 PSL*]
  2. French Direction Generale de l'Armement (DGA)
  3. European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [610110, 819261]
  4. European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant [709104]
  5. Marie Curie Actions (MSCA) [709104] Funding Source: Marie Curie Actions (MSCA)
  6. European Research Council (ERC) [819261] Funding Source: European Research Council (ERC)

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In optical imaging, light propagation is affected by the inhomogeneities of the medium. Sample-induced aberrations and multiple scattering can strongly degrade the image resolution and contrast. On the basis of a dynamic correction of the incident and/or reflected wavefronts, adaptive optics has been used to compensate for those aberrations. However, it only applies to spatially invariant aberrations or to thin aberrating layers. Here, we propose a global and noninvasive approach based on the distortion matrix concept. This matrix basically connects any focusing point of the image with the distorted part of its wavefront in reflection. A singular value decomposition of the distortion matrix allows to correct for high-order aberrations and forward multiple scattering over multiple isoplanatic modes. Proof-of-concept experiments are performed through biological tissues including a turbid cornea. We demonstrate a Strehl ratio enhancement up to 2500 and recover a diffraction-limited resolution until a depth of 10 scattering mean free paths.

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