Journal
FOOD BIOSCIENCE
Volume 35, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fbio.2020.100574
Keywords
Psidium guajava L. leaf; Flavonoids; Anti-hyperglycemic; Liver protection
Categories
Funding
- Scientific Research Project from the Department of Education of Guangdong Province [2013gjhz0003]
- Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods [2018B030322010]
- Guangdong Province Engineering Research Center for Bioactive Natural Products [2016B090920093]
- National Natural Science Foundation of China [31201321]
- Education Department of Hunan Province [B13084]
- China Scholarship Council
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Guava leaf flavonoids were obtained using a simple extraction method to evaluate their anti-hyperglycemic and liver protective effects with a high-fat diet and a low-dose streptozotocin induced diabetic mouse model. Flavonoids supplementation significantly decreased fasting plasma glucose, glucose tolerance, and the insulin resistance index in diabetic mice, lowered the serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol compared to the diabetic control group (p < 0.05). Furthermore, guava leaf flavonoids significantly decreased the liver and kidney indexes, and improved hepatocyte morphology in diabetic mice. Taken together, these results showed that guava leaf flavonoids had significant anti-diabetic and liver protective activities in diabetic mice. This study could facilitate the development of hypoglycemic functional foods from guava leaves.
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