Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2020.00536
Keywords
diabetes mellitus; periodontitis; peri-implant inflammation; periodontal pathogen; bone metabolism; AGEs; vitamin D
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Funding
- Bethune Project of Jilin University of China [2018B02, 2018B08]
- Project of Health and Family Planning Commission of Jilin Province [2017F007]
- Project of Science and Technology Department of Jilin Province [20200201398JC]
- National Natural Science Foundation of China [81903881]
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Diabetes mellitus, a major chronic disease affecting human health, has been increasing in prevalence in recent years. Diabetes mellitus can cause bone metabolic disorders in patients, leading to osteoporosis, a higher risk of traumatic fracture, and other bone diseases. Bone metabolic disorders in the oral cavity principally manifest as periodontitis, loss of alveolar bone, and failure of implant osseointegration. In recent years, numerous studies have shown that there is a complex interaction between bone metabolic disorders and diabetes mellitus. This paper reviews the adverse effects of diabetes on oral bone metabolism disorders such as alveolar osteoporosis and bone loss in patients with periodontitis, discusses the potential mechanisms of diabetic bone loss, and suggests potential ways to prevent and treat oral bone loss in patients with diabetes mellitus.
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