Journal
FRONTIERS IN GENETICS
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2020.00771
Keywords
T cell sequencing; analysis tool; data analysis; Graphic user interface; T cell repertoire
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Funding
- National key project of china [2016YFA0502200]
- China Postdoctoral Science Foundation [2015M582843]
- Basic Science and Frontier Technology Research Project of Chongqing [cstc2017jcyjAX0198]
- Sigrid Juselius Foundation
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Recent progress in high throughput sequencing technologies has provided an opportunity to probe T cell receptor (TCR) repertoire, bringing about an explosion of TCR sequencing data and analysis tools. For easier and more heuristic analysis TCR sequencing data, we developed a client-based HTML program (VisTCR). It has a data storage module and a data analysis module that integrate multiple cutting-edge analysis algorithms in a hierarchical fashion. Researchers can group and re-group samples for different analysis purposes by customized Experiment Design File. Moreover, the VisTCR provides a user-friendly interactive interface, by all the TCR analysis methods and visualization results can be accessed and saved as tables or graphs in the process of analysis. The source code is freely available at https://github.com/qingshanni/VisTCR.
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