Journal
FRONTIERS IN CHEMISTRY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2020.00524
Keywords
glycopolymers; hybrid hydrogels; functionalization strategies; Diels-Alder click reaction; 3D bioprinting; 3D cultures; click chemistry for 3D cellular models
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Funding
- EC [H2020-MSCA-ITN-2014-GA-642028, H2020-NMBP-15-2017-GA-760986]
- Italian Ministry of Health [RF-2016-02362946]
- POR-FESR 2014-2020 Innovazione e Competitivita
- Progetti Strategici di Ricerca, Sviluppo e Innovazione, Azione I.1.b.1.3-IMMUN-HUB-Sviluppo di nuovemolecole di seconda generazione per immunoterapia oncologica
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The development of 3D printable hydrogels based on the crosslinking between chitosan and gelatin is proposed. Chitosan and gelatin were both functionalized with methyl furan groups. Chemical modification was performed by reductive amination with methyl furfural involving the lysine residues of gelatin and the amino groups of chitosan to generate hydrogels with tailored properties. The methyl furan residues present in both polymers were exploited for efficient crosslinking via Diels-Alder ligation with PEG-Star-maleimide under cell-compatible conditions. The obtained chitosan-gelatin hybrid was employed to formulate hydrogels and 3D printable biopolymers and its processability and biocompatibility were preliminarily investigated.
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