Journal
FRONTIERS IN CHEMISTRY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2020.00424
Keywords
graphene quantum dots; synthesis method; bioimaging; fluorescence imaging; two-photon fluorescence imaging
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Funding
- National Key Research and Development Program [2018YFA0704003]
- National Natural Science Foundation of China [31771036, 51703132]
- Basic Research Program of Shenzhen [JCYJ20180507182413022, JCYJ20170412111100742]
- Guangdong Province Natural Science Foundation ofMajor Basic Research and Cultivation Project [2018B030308003]
- Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China [161032]
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Being a zero-dimensional (0D) nanomaterial of the carbon family, graphene quantum dots (GQDs) showed promising biomedical applications owing to their ultra-small size, non-toxicity, biocompatibility, excellent photo stability, tunable fluorescence, and water solubility, etc., thus capturing a considerable attention in biomedical field. This review summarizes the recent advances made in the research field of GQDs and place special emphasis on their bioimaging applications. We briefly introduce the synthesis strategies of GQDs, including top-down and bottom-up strategies. The bioimaging applications of GQDs are also discussed in detail, including optical [fluorescence (FL)], two-photon FL, magnetic resonance imaging (MRI), and dual-modal imaging. In the end, the challenges and future prospects to advance the clinical bioimaging applications of GQDs have also been addressed.
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