Journal
ACS CENTRAL SCIENCE
Volume 6, Issue 9, Pages 1507-1522Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.0c00768
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Funding
- National Natural Science Foundation of China [21975145]
- Natural Science Foundation of Shandong Province [ZR2018ZA0547]
- Program of Qilu Young Scholars of Shandong University
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The enzyme-regulated healable polymeric hydrogels are a kind of emerging soft material capable of repairing the structural defects and recovering the hydrogel properties, wherein their fabrication, self-healing, or degradation is mediated by enzymatic reactions. Despite achievements that have been made in controllable cross-linking and de-cross-linking of hydrogels by utilizing enzyme-catalyzed reactions in the past few years, this substrate-specific strategy for regulating healable polymeric hydrogels remains in its infancy, because both the intelligence and practicality of current man-made enzyme-regulated healable materials are far below the levels of living organisms. A systematic summary of current achievements and a reasonable prospect at this point can play positive roles for the future development in this field. This Outlook focuses on the emerging and rapidly developing research area of bioinspired enzyme-regulated self-healing polymeric hydrogel systems. The enzymatic fabrication and degradation of healable polymeric hydrogels, as well as the enzymatically regulated self-healing of polymeric hydrogels, are reviewed. The functions and applications of the enzyme-regulated healable polymeric hydrogels are discussed.
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