Journal
REDOX BIOLOGY
Volume 37, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.redox.2020.101674
Keywords
Electron transport chain; Mitochondrial reactive oxygen species; Mitochondria; Oxidative phosphorylation
Categories
Funding
- NIH [RO1 HL133003-01A1]
- Hemophilia Center of Western Pennsylvania
- AHA [19POST34380956]
- UPMC Children's Trust Young Investigator Foundation Fund [020284]
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The mitochondrial electron transport chain utilizes a series of electron transfer reactions to generate cellular ATP through oxidative phosphorylation. A consequence of electron transfer is the generation of reactive oxygen species (ROS), which contributes to both homeostatic signaling as well as oxidative stress during pathology. In this graphical review we provide an overview of oxidative phosphorylation and its inter-relationship with ROS production by the electron transport chain. We also outline traditional and novel translational methodology for assessing mitochondrial energetics in health and disease.
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