Journal
FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.01558
Keywords
interleukin-17; cytokine; sepsis; inflammatory response; immune response
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Funding
- National Natural Science Foundation of China [81873946, 81974293, 81730057]
- Key Project of Military Medical Innovation Program of Chinese PLA [18CXZ026]
- National Key Research and Development Program of China [2017YFC1103302]
- Natural Science Foundation of Zhejiang Province [LY20H150011]
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The interleukin (IL)-17 family includes six structure-related cytokines (A-F). To date, majority of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. Several recent studies have indicated that IL-17A is a biomarker as well as a therapeutic target in sepsis. In the current review, we summarize the biological functions of IL-17, including IL-17-mediated responses and signal transduction pathways, with particular emphasis on clinical relevance to sepsis.
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