Journal
FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.01273
Keywords
wound healing; regeneration; cytokines; macrophage migration inhibitory factor (MIF); CD74 receptor; inflammatory bowel disease (IBD); ischemia-reperfusion injury (I; R); lung injury
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Funding
- National Institutes of Health (NIH) [R01AI026649-S1, K08AI119181]
- UVA seed grant
- Robert Wood Johnson Foundation-Harold Amos Medical Faculty Development Program Award
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Wound healing after an injury is essential for life. An in-depth understanding of the healing process is necessary to ultimately improve the currently limited treatment options for patients suffering as a result of damage to various organs and tissues. Injuries, even the most minor, trigger an inflammatory response that protects the host and activates repair pathways. In recent years, substantial progress has been made in delineating the mechanisms by which inflammatory cytokines and their receptors facilitate tissue repair and regeneration. This mini review focuses on emerging literature on the role of the cytokine macrophage migration inhibitory factor (MIF) and its cell membrane receptor CD74, in protecting against injury and promoting healing in different parts of the body.
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