Journal
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
Volume 21, Issue 5, Pages 777-784Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871530320666200729142504
Keywords
Periodontal disease; oral dysbiosis; gut dysbiosis; central nervous system ( CNS) diseases; probiotics; macrophages
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The current treatment and prevention procedures of oral disorders focus on maintaining oral bacteria and hygiene levels separately from systemic microbial homeostasis, which may impact the diagnosis and progression of complex systemic diseases. Imbalance in oral and gut microbiota can lead to various diseases, highlighting the need for a novel philosophical approach in the treatment of oral diseases that considers the interconnectedness of oral and systemic health.
The current treatment and prevention procedures of oral disorders follow a very targeted approach considering mouth and its structures as a system that is completely independent, than the rest of the body. The main therapeutic approach is to keep the levels of oral bacteria and hygiene in an acceptable range compatible with oral-mouth health, completely separated from systemic microbial homeostasis (eubiosis vs dysbiosis). This can negatively impact the diagnosis of a more complex systemic disease and its progression. Dysbiosis occurs as a consequence of imbalance in oral and gut microbiota which leads to cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, and Alzheimer's disease, as reported in current literature. Likewise, there is a need to highlight and develop a novel philosophical approach in the treatments for oral diseases that will necessarily involve nonconventional approaches.
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