Journal
ANNUAL REVIEW OF VIROLOGY, VOL 7, 2020
Volume 7, Issue -, Pages 537-557Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-012220-023606
Keywords
oncolytic parvovirus; oncolytic virus; cancer therapy; H-1PV; combination therapy; second-generation parvoviruses
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Funding
- Luxembourg Cancer Foundation
- Televie
- Cooperational Research Program of the Deutsches Krebsforschungszentrum, Heidelberg
- Ministry of Science and Technology, Israel
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Autonomous rodent protoparvoviruses (PVs) are promising anticancer agents due to their excellent safety profile, natural oncotropism, and on-cosuppressive activities. Viral infection can trigger immunogenic cell death, activating the immune system against the tumor. However, the efficacy of this treatment in recent clinical trials is moderate compared with results seen in preclinical work. Various strategies have been employed to improve the anticancer activities of oncolytic PVs, including development of second-generation parvoviruses with enhanced oncolytic and immunostimulatory activities and rational combination of PVs with other therapies. Understanding the cellular factors involved in the PV life cycle is another important area of investigation. Indeed, these studies may lead to the identification of biomarkers that would allow a more personalized use of PV-based therapies. This review focuses on this work and the challenges that still need to be overcome to move PVs forward into clinical practice as an effective therapeutic option for cancer patients.
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