Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 6, Issue 9, Pages 4985-4992Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c00507
Keywords
hollow mesoporous MnO2 nanoparticles; nanocarriers; MR imaging; tumor microenvironment
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Funding
- National Natural Science Foundation of China [81672851, 81872179]
- Shanghai Municipal Commission of Health and Family Planning [20174Y0229]
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The development of new nanocarriers with desired degradability and targeted ability is of great significance for efficient drug delivery. In this work, a monodisperse hollow structured MnO2 (H-MnO2) with a mesoporous shell is prepared and functionalized for efficient targeted drug delivery. The highly monodisperse H-MnO2 with a uniform morphology was obtained by in situ growing MnO2 on solid silica nanoparticles and subsequently removing the silica core. Then, the H-MnO2 is successively modified with polyethylene glycol and targeted molecule folate (FA). The resultant H-MnO2-FA shows excellent colloidal stability and high drug-loading content (similar to 58.2%) of the antitumor drug doxorubicin hydrochloride (DOX). The H-MnO2-FA possesses acid-responsive T-1-weighted magnetic resonance imaging ability. The pH-dependent biodegradation behavior of H-MnO2-FA is directly observed in vitro and confirmed by in vivo imaging, which is expected to favor the potential clearance of this hollow structured nanocarrier and eliminate its long-term toxicity. In addition, the DOX-loaded H-MnO2-FA also demonstrates excellent cancer cell-killing effect and tumor inhibition efficacy.
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