Journal
STEM CELL REPORTS
Volume 15, Issue 1, Pages 140-155Publisher
CELL PRESS
DOI: 10.1016/j.stemcr.2020.05.017
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Funding
- Canadian Institutes of Health Research (CIHR) [130475]
- CIHR Regenerative Medicine and Nanotechnology grant [RMF92085]
- Canadian Stem Cell Network [SCN CT8]
- CIHR Masters and Doctoral Award
- CIHR Training Program in Regenerative Medicine studentship
- MS Society of Canada Doctoral Scholarship
- CIHR post-doctoral fellowship
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Cell transplantation for spinal cord injury (SCI) has largely been studied in sub-acute settings within 1-2 weeks of injury. In contrast, here we transplanted skin-derived precursors differentiated into Schwann cells (SKP-SCs) into the contused rat spinal cord 8 weeks post-injury (wpi). Twenty-one weeks later (29 wpi), SKP-SCs were found to have survived transplantation, integrated with host tissue, and mitigated the formation of a dense glial scar. Furthermore, transplanted SKP-SCs filled much of the lesion sites and greatly enhanced the presence of endogenous SCs, which myelinated thousands of sprouting/spared host axons in and around the injury site. In addition, SKP-SC transplantation improved locomotor outcomes and decreased pathological thickening of bladder wall. To date, functional improvements have very rarely been observed with cell transplantation beyond the sub-acute stage of injury. Hence, these findings indicate that skin-derived SCs are a promising candidate cell type for the treatment of chronic SCI.
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