4.6 Article

Berberine/Ag nanoparticle embedded biomimetic calcium phosphate scaffolds for enhancing antibacterial function

Journal

NANOTECHNOLOGY REVIEWS
Volume 9, Issue 1, Pages 568-579

Publisher

WALTER DE GRUYTER GMBH
DOI: 10.1515/ntrev-2020-0046

Keywords

calcium phosphate bioceramic; biomimetic scaffold; hierarchical porosity; osteogenesis; antibacterial function

Funding

  1. National Key Research and Development Program of China [2018YFC1106800, 2018YSF1105600]
  2. National Natural Science Foundation of China [31971251]
  3. Sichuan Province Science & Technology Department Projects [2016CZYD0004, 2017SZ0001, 2018GZ0142, 2019YFH0079, 2019JDTD0008]
  4. Research Foundation for Young Teachers of Sichuan University [2018SCUH0017]
  5. 111 Project [B16033]

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In the past decade, biomimetic calcium phosphate (CaP) ceramics have been considered as practicable grafts and biomaterial substitutes in repairing jaw bone defect after tumor resection or traffic accident. Nowadays, increasing incidence of biomedical material-associated infection has raised a concern when applying these materials. In this work, a new porous CaP scaffold with antibacterial coating was proposed. This biomimetic scaffold was composited with berberine (BBR), Ag nanoparticles (nAg), and silk fibroin (SF). The micro-structures and phase composition of the scaffolds were analyzed. The cytocompatibility and osteogenic potential of the prepared samples were evaluated in vitro. The scaffolds held hierarchical structure: the first-level porous CaP ceramic with micron pores ranged from 250 to 600 mu m; the second-level spongy-like structure with abundant capillary pores ranged from 500 nm to 10 mu m; and the third-level structure was achieved by filling BBR, nAg, and SF gel coatings into the above porous structures. The experimental results showed that the antimicrobial capability of single BBR coating is inconspicuous. However, the introduction of nAg could significantly promote the antibacterial effect of scaffolds. At the same time, such scaffolds showed improved osteoinductivity. This new biomimetic CaP scaffold with antibacterial and osteoinductive properties may be a promising candidate for bone tissue engineering.

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