Journal
GENES
Volume 11, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/genes11080858
Keywords
autoimmune thyroid disease; gender; GPR174andITM2A
Categories
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2018R1C1B5084422]
- Korean Health Technology R&D Project, Ministry for Health &Welfare, Republic of Korea [HI14C3417]
- National Research Foundation of Korea [2018R1C1B5084422] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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(1) Background: Autoimmune thyroid diseases (AITDs) are female predominant and much attention has been focused on G protein-coupled receptor 174 (GPR174)and integral membrane protein 2A (ITM2A)on the X chromosome as Grave's disease (GD) susceptible locus. (2) Methods: We genotyped four single nucleotide polymorphisms (SNPs), rs3810712, rs3810711, rs3827440, and rs5912838, ofGPR174andITM2Ain 115 Korean children with AITD (M = 25 and F = 90; GD = 74 (14.7 +/- 3.6 years), HD = 41 (13.4 +/- 3.2 years); GD-thyroid-associated ophthalmopathy (TAO) = 40, GD-non-TAO=34) and 204 healthy Korean individuals (M = 104 and F = 100). The data were analyzed by sex-stratified or combined. (3) Results: Three SNPs, rs3810712, rs3810711 and rs3827440, were found to be in perfect linkage disequilibrium (D' = 1, r(2)= 1). In AITD, HD, GD, GD-TAO, and GD-non-TAO patients, rs3827440 TT/T and rs5912838 AA/A were susceptible and rs3827440 CC/C and rs5912838 CC/C were protective genotypes. When analyzed by sex, rs3827440 TT and rs5912838 AA were susceptible and rs3827440 CC and rs5912838 CC were protective genotypes in female AITD, GD, GD-TAO, and GD-non-TAO subjects. In male AITD patients, rs3827440 T and rs5912838 A were susceptible and rs3827440 C and rs5912838 C were protective genotypes. (4) Conclusions: Polymorphisms inGPR174andITM2Agenes on the X chromosome might be associated with AITD in Korean children.
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