4.6 Review

Experimental Approaches in Delineating mTOR Signaling

Related references

Note: Only part of the references are listed.
Review Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Grace Y. Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

Anders P. Mutvei et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Control of mTOR signaling by ubiquitin

Yao Jiang et al.

ONCOGENE (2019)

Article Cell Biology

Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment

Brittany Angarola et al.

MOLECULAR BIOLOGY OF THE CELL (2019)

Article Multidisciplinary Sciences

Structural basis for the docking of mTORC1 on the lysosomal surface

Kacper B. Rogala et al.

SCIENCE (2019)

Review Cell Biology

mTOR as a central hub of nutrient signalling and cell growth

Joungmok Kim et al.

NATURE CELL BIOLOGY (2019)

Article Cell Biology

Cryo-EM structure of human mTOR complex 2

Xizi Chen et al.

CELL RESEARCH (2018)

Article Biology

Architecture of the human mTORC2 core complex

Edward Stuttfeld et al.

ELIFE (2018)

Article Multidisciplinary Sciences

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

Kuang Shen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Oncology

mTOR signalling and cellular metabolism are mutual determinants in cancer

Dirk Mossmann et al.

NATURE REVIEWS CANCER (2018)

Article Multidisciplinary Sciences

SZT2 dictates GATOR control of mTORC1 signalling

Min Peng et al.

NATURE (2017)

Article Multidisciplinary Sciences

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

Haijuan Yang et al.

NATURE (2017)

Article Multidisciplinary Sciences

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Rachel L. Wolfson et al.

NATURE (2017)

Article Multidisciplinary Sciences

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

Xin Gu et al.

SCIENCE (2017)

Review Medicine, Research & Experimental

Understanding the mTOR signaling pathway via mathematical modeling

Nurgazy Sulaimanov et al.

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2017)

Article Multidisciplinary Sciences

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

Manikandan Karuppasamy et al.

NATURE COMMUNICATIONS (2017)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease

Robert A. Saxton et al.

Article Cell Biology

Unraveling the regulation of mTORC2 using logical modeling

Kirsten Thobe et al.

CELL COMMUNICATION AND SIGNALING (2017)

Article Multidisciplinary Sciences

METABOLISM Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

Robert A. Saxton et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

METABOLISM Sestrin2 is a leucine sensor for the mTORC1 pathway

Rachel L. Wolfson et al.

SCIENCE (2016)

Article Biochemistry & Molecular Biology

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

Lynne Chantranupong et al.

Article Cell Biology

4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1

Huirong Yang et al.

PROTEIN & CELL (2016)

Review Neurosciences

Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function

Carla Garza-Lombo et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2016)

Article Biochemistry & Molecular Biology

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin et al.

Article Multidisciplinary Sciences

Identification of an oncogenic RAB protein

Douglas B. Wheeler et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Shuyu Wang et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Differential regulation of mTORC1 by leucine and glutamine

Jenna L. Jewell et al.

SCIENCE (2015)

Article Oncology

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

Pengda Liu et al.

CANCER DISCOVERY (2015)

Article Multidisciplinary Sciences

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

Jeong Sig Kim et al.

SCIENTIFIC REPORTS (2015)

Review Biochemistry & Molecular Biology

mTOR signaling in tumorigenesis

Kai Xu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2014)

Article Cell Biology

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

Anita Parmigiani et al.

CELL REPORTS (2014)

Article Biochemistry & Molecular Biology

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

Zhi-Yang Tsun et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

mTOR kinase structure, mechanism and regulation

Haijuan Yang et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels tomTORC1

Liron Bar-Peled et al.

Article Biochemistry & Molecular Biology

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

Jung Min Han et al.

Article Biochemistry & Molecular Biology

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

Christian C. Dibble et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

Laura R. Pearce et al.

BIOCHEMICAL JOURNAL (2011)

Article Biochemistry & Molecular Biology

Activation of mTORC2 by Association with the Ribosome

Vittoria Zinzalla et al.

Article Biochemistry & Molecular Biology

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Timothy R. Peterson et al.

Article Biochemical Research Methods

A High-Throughput, Cell-Based Screening Method for siRNA and Small Molecule Inhibitors of mTORC1 Signaling Using the In Cell Western Technique

Gregory R. Hoffman et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2010)

Article Biochemistry & Molecular Biology

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

Calvin K. Yip et al.

MOLECULAR CELL (2010)

Article Multidisciplinary Sciences

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

Jun Hee Lee et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling

Andrei V. Budanov et al.

Article Cell Biology

Regulation of ceramide biosynthesis by TOR complex 2

Sofia Aronova et al.

CELL METABOLISM (2008)

Article Cell Biology

Regulation of TORC1 by Rag GTPases in nutrient response

Eunjung Kim et al.

NATURE CELL BIOLOGY (2008)

Article Multidisciplinary Sciences

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Yasemin Sancak et al.

SCIENCE (2008)

Article Biochemistry & Molecular Biology

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Laura R. Pearce et al.

BIOCHEMICAL JOURNAL (2007)

Article Biochemistry & Molecular Biology

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Yasemin Sancak et al.

MOLECULAR CELL (2007)

Article Biochemistry & Molecular Biology

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

Maria A. Frias et al.

CURRENT BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

Y Kamada et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Rheb binds and regulates the mTOR kinase

X Long et al.

CURRENT BIOLOGY (2005)

Review Cell Biology

Upstream and downstream of mTOR

N Hay et al.

GENES & DEVELOPMENT (2004)

Article Cell Biology

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Y Zhang et al.

NATURE CELL BIOLOGY (2003)

Article Cell Biology

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

H Stocker et al.

NATURE CELL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

A Garami et al.

MOLECULAR CELL (2003)

Article Multidisciplinary Sciences

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

AR Tee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Cell Biology

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

K Inoki et al.

NATURE CELL BIOLOGY (2002)

Article Cell Biology

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

XS Gao et al.

NATURE CELL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

K Hara et al.

Article Multidisciplinary Sciences

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

T Kobayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Cell Biology

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

XS Gao et al.

GENES & DEVELOPMENT (2001)

Article Biochemistry & Molecular Biology

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine

R Weisman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Cell Biology

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

HB Zhang et al.

GENES & DEVELOPMENT (2000)

Article Biochemistry & Molecular Biology

The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

J Urano et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)