Synthesis of quinozilinium fluoroborate salts from harmine

Molecules possessing harmine moiety are reported to exhibit marked fungicidal and bactericidal activities. In this study, various quinozilinium tetrafluoroborate salts were synthesized using acylic and cyclic oxoketene dithioacetals followed by cycloaromatization from Harmine. All of these synthesized compounds were characterized by H-1 NMR, C-13 NMR, Mass and CHN analysis. This methodology would find wide usage in the preparation of indolo quinozilinium -based library of small molecules useful for medicinal chemistry and in drug discovery. [GRAPHICS] .

Automated summary

Molecules with harmine moiety have been shown to have strong fungicidal and bactericidal activities. Various quinozilinium tetrafluoroborate salts were synthesized in this study and characterized via multiple analytical techniques, showing potential for the preparation of a library of small molecules useful in medicinal chemistry and drug discovery.