Anti-obesity, anti-hyperglycaemic, anti-antipyretic and analgesic activities ofGlobularia alypumextracts

Objectives:The aim of this study is to evaluate the anti-obesity, anti-hyperglycaemic, analgesic and antipyretic activities ofGlobularia alypum(GA). Materials and methods:GA methanol and water extracts (GAME, GAWE) were administered to high-fat-high-glucose diet (HFFD) rats. Results:This study showed that GAME exhibited the highest antioxidant, anti-alpha-amylase and anti-lipase activities, with half inhibitory concentration (IC50) values 0.067, 1.05 and 2.97 mg/ml respectively. In HFFD rats, the administration of GAME inhibited lipase activity by 36, 37 and 30% in the intestine, pancreas and serum, respectively, reduced body weight by 17.7% and modulated lipid profile. In addition, administration of GAME to HFFD-rats decreased alpha-amylase activity, improved glucose level and protected liver function. Furthermore, the administration of GA extracts to rats revealed antipyretic (reduction in writhing by 64%) and analgesic (decrease of temperature by 1.11 degrees C) activities. Conclusion:This study showed that GA extracts exhibited an anti-obesity, anti-hyperglycaemia, anti-pyretic and analgesic activities.

Automated summary

This study found that extracts of Globularia alypum exhibited anti-obesity, anti-hyperglycaemic, antipyretic, and analgesic activities.