Journal
ADVANCED MATERIALS INTERFACES
Volume 7, Issue 18, Pages -Publisher
WILEY
DOI: 10.1002/admi.202000699
Keywords
bioelectronics; biointerfaces; biomaterials; graphene; out-of-plane structures; SEM; FIB
Funding
- National Science Foundation [CBET1552833]
- Office of Naval Research [N000141712368]
- Department of Materials Science and Engineering Materials Characterization Facility [MCF-677785]
- U.S. Department of Defense (DOD) [N000141712368] Funding Source: U.S. Department of Defense (DOD)
Ask authors/readers for more resources
The cell-chip coupling is in general regulated by the interplay between cells and the material surface at the interface. Electroactive planar materials have shown limited crosstalk with cells, whereas pseudo 3D patterned materials promote a more intimate contact with the biological system. Here, unprecedented physical properties of a carbon-based material, i.e., graphene, to engineer out-of-plane morphologies are exploited: 1) 3D single- to few-layer fuzzy graphene morphology (3DFG), 2) 3DFG on a collapsed Si nanowire mesh template, and 3) 3DFG on a noncollapsed Si nanowire mesh template. These materials are synthesized and interfaced with cardiomyocyte-like cells focusing on the characterization of the cytoskeletal arrangement as well as membrane wrapping processes yet regulated by endocytic proteins. Finally, some major conditions to promote tight coupling to the device and eventually spontaneous intracellular penetration are found.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available