Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 140, Issue -, Pages 430-436Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2015.12.055
Keywords
Bone tissue engineering; Cell proliferation; Magnetic stimulus; Magnetoelectric
Funding
- FEDER through the Programa Operacional Fatores de Competitividade-COMPETE
- FCT-Fundacao Para a Ciencia e a Tecnologia [PEST-C/FIS/UI607/2014]
- FCT [SFRH/BPD/90870/2012, SFRH/BPD/96227/2013, SFRH/BPD/97739/2013]
- Basque Government Industry Department under the ELKARTEK Program
- Diputacion de Bizkaia
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A novel approach for tissue engineering applications based on the use of magnetoelectric materials is presented. This work proves that magnetoelectric Terfenol-D/poly(vinylidene fluoride-co-trifluoroethylene) composites are able to provide mechanical and electrical stimuli to MC3T3-E1 pre-osteoblast cells and that those stimuli can be remotely triggered by an applied magnetic field. Cell proliferation is enhanced up to approximate to 25% when cells are cultured under mechanical (up to 110 ppm) and electrical stimulation (up to 0.115 mV), showing that magnetoelectric cell stimulation is a novel and suitable approach for tissue engineering allowing magnetic, mechanical and electrical stimuli. (C) 2015 Elsevier B.V. All rights reserved.
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