Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 139, Issue -, Pages 10-16Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2015.12.004
Keywords
Adjuvant; Rod-shaped HA; Substitution; Th1 immunity; Th2 immunity
Funding
- KAKENHI [26750162, 23700567]
- Grants-in-Aid for Scientific Research [23700567, 26750162] Funding Source: KAKEN
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A Th1 immune response is required for modern vaccines as the most commonly used alum adjuvant has weak capacity for inducing Th1 immune response. Herein, rod-shaped hydroxyapatite (HA), magnesium substituted HA (MgHA) and zinc-substituted HA (ZnHA) nanoparticles with irregular nanopores were synthesized and used as immunoadjuvants. Magnesium and zinc substitution in HA showed no influence on morphology, particle size, zeta potential and surface area of the nanoparticles. The rod-shaped MgHA and ZnHA nanoparticles promoted the cellular uptake of a molecular immunopotentiator, stimulated both type 1 and 2 cytokine secretion in vitro that relate to Th1 and Th2 immunity of bone marrow dentritic cells, respectively. The MgHA and ZnHA nanoparticles may be useful as immunoadjuvants for human. (C) 2015 Elsevier B.V. All rights reserved.
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