Journal
JOURNAL OF DIABETES RESEARCH
Volume 2020, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2020/3960857
Keywords
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Funding
- Ningbo Science and Technology Innovation Team Program [2014B82002]
- Ningbo 3315 Program [2013A-10-G]
- Fang Runhua Fund of Hong Kong
- K.C. Wong Magna Fund in Ningbo University
- Ningbo Public Welfare Science and Technology Project [2019C50080]
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The correlation between diabetes and systematic well-being on human life has long established. As a common complication of diabetes, the prevalence of diabetic nephropathy (DN) has been increasing globally. DN is known to be a major cause of end-stage kidney disease (ESKD). Till now, the molecular mechanisms for DN have not been fully explored and the effective therapies are still lacking. Noncoding RNAs are a class of RNAs produced by genome transcription that cannot be translated into proteins. It has been documented that ncRNAs participate in the pathogenesis of DN by regulating inflammation, apoptosis, autophagy, cell proliferation, and other pathological processes. In this review, the pathological roles and diagnostic and therapeutic potential of three types of ncRNAs (microRNA, long noncoding RNA, and circular RNA) in the progression of DN are summarized and illustrated.
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