Journal
FRONTIERS IN MICROBIOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.01511
Keywords
HCMV; virion-carried molecules; primary infection; reactivation; tegument; envelope
Categories
Funding
- National Key Research and Development Program of China [2017YFA0104500]
- National Natural Science Foundation of China [81670166, 81530046, 81870140]
- Innovative Research Groups of the National Natural Science Foundation of China [81621001]
- Beijing Municipal Science & Technology Commission [Z171100001017098]
- Project of Health Collaborative Innovation of Guangzhou City [201704020214]
- Scientific Research Foundation for Capital Medicine Development [2018-2-4084]
- Peking University Clinical Scientist Program [BMU2019LCKXJ003]
- Clinical Medicine Plus X-Young Scholars Project of Peking University - the Fundamental Research Funds for the Central Universities [PKU2020LCXQ015]
- Peking University People's Hospital Research and Development Funds [RDX2019-14]
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Human cytomegalovirus (HCMV), a ubiquitous beta-herpesvirus, is able to establish lifelong latency after initial infection. Periodical reactivation occurs after immunosuppression, remaining a major cause of death in immunocompromised patients. HCMV has to reach a structural and functional balance with the host at its earliest entry. Virion-carried mediators are considered to play pivotal roles in viral adaptation into a new cellular environment upon entry. Additionally, one clear difference between primary infection and reactivation is the idea that virion-packaged factors are already formed such that those molecules can be used swiftly by the virus. In contrast, virion-carried mediators have to be transcribed and translated; thus, they are not readily available during reactivation. Hence, understanding virion-carried molecules helps to elucidate HCMV reactivation. In this article, the impact of virion-packaged molecules on viral structure, biological behavior, and viral life cycle will be reviewed.
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