Journal
FRONTIERS IN MICROBIOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.01457
Keywords
Gram-positive bacteria; adhesins; physical stress; force; staphylococcus; atomic force microscopy
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Funding
- Excellence of Science-EOS program [30550343]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [693630]
- FNRS-WELBIO [WELBIO-CR-2015A-05]
- National Fund for Scientific Research (FNRS)
- Research Department of the Communaute francaise de Belgique (Concerted Research Action)
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Bacterial pathogens are equipped with specialized surface-exposed proteins that bind strongly to ligands on host tissues and biomaterials. These adhesins play critical roles during infection, especially during the early step of adhesion where the cells are exposed to physical stress. Recent single-molecule experiments have shown that staphylococci interact with their ligands through a wide diversity of mechanosensitive molecular mechanisms. Adhesin-ligand interactions are activated by tensile force and can be ten times stronger than classical non-covalent biological bonds. Overall these studies demonstrate that Gram-positive adhesins feature unusual stress-dependent molecular interactions, which play essential roles during bacterial colonization and dissemination. With an increasing prevalence of multidrug resistant infections caused byStaphylococcus aureusandStaphylococcus epidermidis, chemotherapeutic targeting of adhesins offers an innovative alternative to antibiotics.
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