Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 8, Issue 32, Pages 12230-12238Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.0c03816
Keywords
Active pharmaceutical ingredients (APIs); Green chemistry; Hydantoins; Hydrazones; Mechanochemistry; Solven ree; Twin-screw extrusion (TSE)
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Funding
- COST (European Cooperation in Science and Technology) [CA18112,43-45]
- MIUR [2017B7MMJ5_001]
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Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.
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