Journal
POLYMERS
Volume 12, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/polym12071521
Keywords
lycopene; psoriasis
Categories
Funding
- National Science Council in Taiwan [MOST 108-2320-B-038-046]
- Taipei Medical University -National Taiwan University of Science and Technology Joint Research Program [TMU-NTUST-109-03]
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Lycopene is the most abundant carotenoid in tomatoes, which has been identified to have the properties of anti-inflammation in addition to the capability to inhibit the expression of adhesion molecules. Intercellular adhesion molecules play a critical role in the pathogenesis of psoriasis. Here, we report that the topical use of a lycopene decreased imiquimod (IMQ)-induced psoriasis-like inflammatory responses, the progress of which was based on adhesion molecules. In vitro analysis showed that lycopene decreased keratinocyte and monocyte adhesion. Evidence suggests that intercellular adhesion molecule-1 (ICAM-1) is a main mediator of psoriasis pathogenesis. Therefore, it will be interesting to investigate the factors that contribute to the lycopene-mediated inhibition of ICAM-1 expression in psoriasis. We expect that lycopene will with potential value in the treatment of psoriasis.
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