Journal
POLYMERS
Volume 12, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/polym12071459
Keywords
interpolymer complexes; Eudragit(R); indomethacin; oral drug delivery; biorelevant media; controlled drug delivery; drug delivery systems
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Funding
- Russian Science Foundation (RSF) [14-15-01059]
- Kazan State Medical University
- Russian Science Foundation [14-15-01059] Funding Source: Russian Science Foundation
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Interpolymer complexes (IPC) based on Eudragit(R)EPO and Eudragit(R)S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40,% v/v) and tetrahydrofuran). According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit(R) S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains. IPC have pH-independent swelling properties in the media mimicking gastrointestinal tract (GIT) conditions and provide colon-specific delivery of indomethacin in buffer solutions (pH 1.2; 5.8; 6.8; 7.4) and in biorelevant media (fasted state simulated gastric fluid, fasted state simulated intestinal fluid-version 2 and fasted stated simulated colonic fluid).
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