Journal
POLYMERS
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/polym12081808
Keywords
statistical copolymer; 2-methoxyethyl acrylate; 2-methacryloyloxyethyl phosphorylcholine; self-association behavior
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Funding
- Japan Society for the Promotion of Science (JSPS) [17H03071]
- JSPS [JPJSBP120203509]
- Cooperative Research Program of Network Joint Research Center for Materials and Devices [20204034]
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Biocompatible amphiphilic statistical copolymers P(MEA/MPCm) composed of 2-methoxyethyl acrylate (MEA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) were prepared with three different mol% of the hydrophilic unit MPC (m= 6, 12 and 46 mol%). The monomer reactivity ratios of MEA (r(MEA)) and MPC (r(MPC)) were 0.53 and 2.21, respectively. Ther(MEA)xr(MPC)value of 1.17 demonstrated that statistical copolymerization was successful. P(MEA/MPC12) and P(MEA/MPC46) copolymers did not undergo aggregation in water, whereas the P(MEA/MPC6) copolymer formed micelles in water with a hydrodynamic radius (R-h) of 96.9 nm and a critical aggregation concentration, which was determined using pyrene fluorescence, at 0.0082 g/L. The restricted motion of the protons in the hydrophobic MEA units in the micelles' cores provided additional evidence of self-association in P(MEA/MPC6).
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