4.6 Review

Genomic instability and cancer: lessons from Drosophila

Journal

OPEN BIOLOGY
Volume 10, Issue 6, Pages -

Publisher

ROYAL SOC
DOI: 10.1098/rsob.200060

Keywords

Drosophila; genomic instability; DNA damage; cancer; aneuploidy

Funding

  1. Novo Nordisk Foundation [NNF0052223]
  2. Neye Foundation for genetic models for cancer gene discovery

Ask authors/readers for more resources

Cancer is a genetic disease that involves the gradual accumulation of mutations. Human tumours are genetically unstable. However, the current knowledge about the origins and implications of genomic instability in this disease is limited. Understanding the biology of cancer requires the use of animal models. Here, we review relevant studies addressing the implications of genomic instability in cancer by using the fruit fly, Drosophila melanogaster, as a model system. We discuss how this invertebrate has helped us to expand the current knowledge about the mechanisms involved in genomic instability and how this hallmark of cancer influences disease progression.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available