Journal
MATERIALS EXPRESS
Volume 10, Issue 6, Pages 934-941Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/mex.2020.1707
Keywords
Metal-Organic Framework; Drug Delivery; 5-Fluorouracil; Cytotoxicity Assay
Funding
- National Natural Science Foundation of Civangdong Province [2017A030310666, 2018A030307003]
- Guangdong Medical University Nanhai Marine Biomedical Resources R&D Public Service Platform Open Fund Project [2HC18013, 2HC18016]
- Group-type Special Support Project for Education Talents in Universities [4SG19045G]
- Foundation of Young Innovative Talents in Guangdong Province Colleges [2018KQNCX091]
- Undergraduate Science&Technology Innovation Foundation of Guangdong Province [201810571046, 201810571073]
- Medical Science and Technology Development Foundation of Guangdong Province [A2016355]
- Stale Key Laboratory of Molecular Engineering of Polymers (Fudan University)
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In this study, the [Zn(4,4'-bipy)(formic acid)(2) (NO3)(2)] (4,4' -bipy = 4,4'-bipyridine) metal-organic framework (MOF) (1) was synthesized using Zn(NO3)(2)center dot 6H(2)O and 4,4'-bipyridine according to the solution solvothermal approach. In addition, thermogravimetric analysis (TGA), power X-ray diffraction (XRD), UV spectrophotometry, and Fourier transform infrared spectroscopy (FTIR) were carried out to determine the crystal phase and characterizations of 1. Thereafter, 1 was adopted to carry 5-fluorouracil (5-FU), which displayed a 5-FU loading of 37.9 wt%. Besides, the 5-FU-loaded 1 displayed pH-sensitive behavior with the release of 5-FU in acidic environment. Typically, the 5-FU release process was progressive and under efficient control, and 93% 5-FU was released in acidic environment at 72 h later, but only 58% 5-FU was released in the phosphate buffered saline (PBS, pH = 7.4). Furthermore, the toxicity of 1 was evaluated through cytotoxicity assays in HeLa and L02 cell lines, which showed significantly low toxicity of 1. Taken together, these results indicate that, the prepared 1 may potentially serve as a suitable carrier for drug delivery applications.
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