Effect of Korean Red Ginseng through comparative analysis of cardiac gene expression in db/db mice

Korean Red Ginseng (KRG) is an herbal oriental medicine known to alleviate cardiovascular dysfunction. To analysis the expression of diabetic cardiac complication-associated genes in db/db mice, we studied the cardiac gene expression following KRG treatment. In result, a total of 585 genes were found to be changed in db/db mice. Among the changed expression, 245 genes were found to 2-fold upregulated, and 340 genes were 2-fold downregulated. In addition, the changed gene expressions were ameliorated by KRG. In conclusion, KRG may be possible to normalize cardiac gene expressions in db/db mice. (C) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V.

Automated summary

The study suggests that Korean Red Ginseng may help normalize cardiac gene expressions in diabetic mice, alleviate cardiovascular dysfunction by regulating the expression of associated genes.