Journal
G3-GENES GENOMES GENETICS
Volume 10, Issue 9, Pages 3271-3278Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.120.401547
Keywords
Atoh1; glia; lin-32; neuroD1; neurog1
Categories
Funding
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- NIH R01 [NS094171, NS105638]
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The regulation of gliogenesis is a fundamental process for nervous system development, as the appropriate glial number and identity is required for a functional nervous system. To investigate the molecular mechanisms involved in gliogenesis, we used C. elegans as a model and identified the function of the proneural gene lin-32/Atoh1 in gliogenesis. We found that lin-32 functions during embryonic development to negatively regulate the number of AMsh glia. The ectopic AMsh cells at least partially arise from cells originally fated to become CEPsh glia, suggesting that lin-32 is involved in the specification of specific glial subtypes. Moreover, we show that lin-32 acts in parallel with cnd-1/ NeuroD1 and ngn-1/ Neurog1 in negatively regulating an AMsh glia fate. Furthermore, expression of murine Atoh1 fully rescues lin-32 mutant phenotypes, suggesting lin-32/Atoh1 may have a conserved role in glial specification.
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