Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2020.00217
Keywords
advanced glycation end products; RAGE; Alzheimer's disease; diabetes; PI3K
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Funding
- National Natural Science Foundation of China [81571345, 81701732]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- Shanghai Municipal Key Clinical Specialty [shslczdzk03402]
- ZJLab
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Diabetes and Alzheimer's disease (AD) place a significant burden on health care systems in the world and its aging populations. These diseases have long been regarded as separate entities; however, advanced glycation end products (AGEs) and the receptors for AGEs (RAGE) may be a link between diabetes and AD. In our study, mice injected with AGEs through stereotaxic surgery showed significant AD-like features: behavior showed decreased memory; immunofluorescence showed increased phosphorylated tau and APP. These results suggest links between diabetes and AD. Patients with diabetes are at a higher risk of developing AD, and the possible underlying molecular components of this association are now beginning to emerge.
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